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KMID : 1123920140280040371
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Korean Journal of Oriental Physiology and Pathology
2014 Volume.28 No. 4 p.371 ~ p.378
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Effects of Kyeongok-go and Its Two Added Precriptions on Hyperlipidemic Rats Induced by High-fat Diet
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Kim Jeung-Beum
Song Hyo-Nam
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Abstract
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This study was designed to investigate the antihyperlipidemic activity of aqueous extracts of Kyeongokgo (KOG), Kyeongokgo Dansambang (KDB), and Kyeongokgo Gamibang (KGB) on the hyperlipidemic rats induced by high-fat diet. The animals were divided into 4 groups of the hyperlipidemic control group, the KOG-fed group, the KDB-fed group and the KGB-fed group, and received oral administration of each prescription with diet for a period of six weeks. The changes in the body weight, the amount of food intake, the liver weight, the epididymal fat weight, and the plasma levels of total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol were measured. In all experimental groups, the weight of liver and epididymal fat decreased significantly. There was a significant decrease in the amount of food intake, the weight of liver and epididymal fat, the plasma level of total cholesterol, and HDL-cholesterol in the KDB-fed and the KGB-fed groups. In addition, KGB-fed group represented a significant decrease in the triglyceride. These results suggest that the aqueous extracts of Kyeongokgo Dansambang and Kyeongokgo Gamibang have a good antihyperlipidemic activity and a potential to treat hyperlipidemia.
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KEYWORD
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Kyeongok-go(瓊玉膏), hyperlipidemia, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol
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